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Neuroradiological Features of Six Kindreds with MELAS tRNA(Leu) A3243G Point Mutation: Implications for Pathogenesis JNNP 65:233-240, Sue,C.M.,et al, 1998 See this aricle in Pubmed Article Abstract These radiological findings, when considered in the context of the clinical and pathological findings, seem to reflect two major disease processes; an intermittent abrupt loss of function associated with cell injury from which there is at le ast partial recovery and a slowly progressive degenerative process causing basal ganglia calcification, and cerebral and cerebellar atrophy. The clinical and radiological features resulting from these processes are distinctive and provide insight into th e consequences of mitochondrial dysfunction on the brain.

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(click to filter results - removes previous filter) basal ganglia,calcification of calcification,intracranial CAT scan CAT scan,abnormal cerebellar atrophy,secondary cerebellar degeneration cerebellar lesion cerebral cortical atrophy fourth ventricle,enlargement of MELAS syndrome mitochondrial disease neuropathology neuroradiology

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